Evaluation of endothelial and platelet functions with intergenotypic variation of eNOS Glu298Asp gene polymorphism in relation to postmenopausal women
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P-235: No Association of Endothelial Nitric Oxide Synthase (eNOS) -786T/C Polymorphism with Unexplained Recurrent Abortion in Iranian Women
Background: This is a case-control study to determine the relationship between endothelial nitric oxide synthase (eNOS) gene -786T/C polymorphism in women with unexplaiend recurrent abortion in comparison with healty women.Materials and Methods: 95 women with history of at least 2 unexplaiend recurrent abortion in the reproductive age range 20-35 years as patients group and 95 healty women (age...
متن کاملAssociation of endothelial nitric oxide synthase gene G894T polymorphism with type two diabetes and diabetic nephropathy
Background: Nitric oxide (NO) produced by endothelial NO synthase (eNOS) mediates a large range of processes, and abnormality in the production of NO has been implicated in diabetic complications including diabetic nephropathy (DN). G894T polymorphism in the eNOS gene has been shown to decreased activity the NO levels of plasma. The association between eNOS Glu298Asp gene polymorphism and DN ri...
متن کاملRole of Enos (glu298asp) Gene Polymorphism and Intergenotypic Variation of Nitric Oxide and Inflammatory Cytokines in Preeclampsia. Deepika Sharma1*, Shubha. S. Trivedi and Jayashree Bhattacharjee
ABSTRACT Problem Multiple etiologies are available for understanding the mechanisms responsible for the syndrome of Preeclampsia. Cytokine imbalance and endothelial dysfunction is suggested to have a pivotal role. The pathophysiological processes in preeclampsia (PE) are also influenced by genetic factors. To characterize the host genetic factors determining the susceptibility to Preeclampsia, ...
متن کاملEndothelial nitric oxide synthase gene Glu298Asp polymorphism is associated with advanced stage endometriosis.
BACKGROUND Altered expression of endothelial nitric oxide synthase (eNOS) has been reported to be involved in the development of endometriosis. The genotypes of eNOS gene (NOS3) may be responsible for variation in its enzymatic activity as well as plasma concentration of nitric oxide. The Glu298Asp polymorphism of the NOS3 may modulate angiogenesis and influence individual susceptibility to end...
متن کاملAssociation of Endothelial Dysfunction with Endothelin, Nitric Oxide and eNOS Glu298Asp Gene Polymorphism in Coronary Artery Disease
The endothelial dysfunction has been implicated as a major event in the pathogenesis of atherosclerosis. Therefore, this study was planned to determine (a) role of endothelium-derived nitric oxide (NO) and endothelin as coronary artery disease (CAD) risk markers and (b) intergenotypic variation of endothelial nitric oxide synthase (eNOS) Glu298Asp polymorphism in CAD.The endothelin, NO and eNOS...
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تاریخ انتشار 2010